Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities
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Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities

Migliavacca, Eugenia;Tay, Stacey K. H.;Patel, Harnish P.;Sonntag, Tanja;Civiletto, Gabriele;McFarlane, Craig;Forrester, Terence;Barton, Sheila J.;Leow, Melvin K.;Antoun, Elie;Charpagne, Aline;Chong, Yap Seng;Descombes, Patrick;Feng, Lei;Francis-Emmanuel, Patrice;Garratt, Emma S.;Giner, Maria Pilar;Green, Curtis O.;Karaz, Sonia;Kothandaraman, Narasimhan;Marquis, Julien;Metairon, Sylviane;Moco, Sofia;Nelson, Gail;Ngo, Sherry;Pleasants, Tony;Raymond, Frederic;Sayer, Avan A.;Sim, Chu Ming;Slater-Jefferies, Jo;Syddall, Holly E.;Tan, Pei Fang;Titcombe, Philip;Vaz, Candida;Westbury, Leo D.;Wong, Gerard;Yonghui, Wu;Cooper, Cyrus;Sheppard, Allan;Godfrey, Keith M.;Lillycrop, Karen A.;Karnani, Neerja;Feige, Jerome N.;
Nature communications 2019 Vol. 10 pp. 1-14
172
migliavacca2019mitochondrialnature

Abstract

Sarcopenia is the loss of muscle mass and strength associated with physical disability during ageing. Here, the authors analyse muscle biopsies from 119 patients with sarcopenia and age-matched controls of different ethnic groups and find transcriptional signatures indicating mitochondrial dysfunction, associated with reduced mitochondria numbers and lower NAD+ levels in older individuals with sarcopenia.

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Technology (General) Science business petroleum refining. petroleum products management. industrial management fine arts

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