Numerous studies prove the efficacy of internet-based self-help programs, but integration into the health-care system was rarely investigated. The present study addresses the implementation of an internet-based self-help program into routine care of patients with depressive symptoms waiting for psychotherapy at the university outpatient center.Patients waiting for outpatient psychotherapy were randomly assigned to either a control group or an intervention group that received access to the internet-based program Deprexis during the waiting period. Depressive symptoms were assessed before and after waiting. Additionally, expectations and program use of participants were exploratively examined.Only half of the patients who were informed about the study were interested in participation. Participants used about half of the modules in the program Deprexis. Depressive symptoms were reduced in both groups during the waiting time. However, the symptom improvements were not significant.Integration of internet-based self-help programs into the German health-care system should include support by a psychotherapist. Preferences of participants should also be considered to enhance adherence and efficacy of the program.Internet-based self-help programs for use in the waiting time for outpatient psychotherapy of patients with depression should involve guidance.