Mg-based implants are used in biomedical applications predominantly because of their degradable property. In this paper, the effect of local misorientations (intragranular misorientation) on the corrosion behavior of high-purity Mg (HPM) was systematically investigated according to microstructure characterization and corrosion measurements. The results showed that local misorientation introduced into grains by deformation could result in corrosion around the grain boundary (GB), which ultimately reduces the corrosion resistance of HPM. After removing the local misorientation by annealing, the corrosion around GB could be eliminated. This work is expected to inspire better control over the degradation behaviors of biomedical Mg through microstructure design to be used for various biomedical applications.