The VUCA era requires the role of leadership agility and organizational commitment for organizational readiness for change. For its readiness to change, the Public Islamic Universities in Central Java require leadership agility and organizational commitment from the academic community. This study aims to test the influence of Leadership Agility and Organizational Commitment toward Organizational Readiness for Change. This study is conducted in five Public Islamic Universities in Central Java, namely Institut Agama Islam Negeri (IAIN) Pekalongan, Universitas Islam Negeri (UIN) Semarang, Institut Agama Islam Negeri (IAIN) Salatiga, Institut Agama Islam Negeri (IAIN) Purwokerto, Institut Agama Islam Negeri (IAIN) Surakarta. These five universities have done the practice of leadership agility. The respondent of this study is 100 people, which taken using disporportional or disporportionate stratified random sampling method. This method is done by taking sample with not paying attention to the comparison of the number of members between subpopulation. The data analysis is performed using Partial Least Square. The result of this study shows that the variable of Leadership Agility has an influence toward Organizational Readiness for Change of0.625, while Organizational Commitment has an influence of 0.264.The result of this study is expected to be used in creating guidelines for Leadership Agility, building agile value, principles, and implementation or agile practice in Public Islamic Universities in Central Java.