In order to study the features of hemodynamics in the vertebral artery (VA), depending on the biomechanical disorders of the cervical spine (CS) and the musculoskeletal system as a whole 105 patients (53 females and 52 males, mean age - 38±5,9 years) having signs of the Vertebrobasilar insufficiency on the background of biomechanical disorders of the CS and the locomotor system as a whole were examined. The control group included 50 practically healthy persons (25 females and 25 males, mean age - 37±5,6 years). Physical examination included a clinical-neurological, vertebro-neurological examination (visual assessment of violations of statics and dynamics of the musculoskeletal system, measuring the craniovertebral angle (CVA) using a photogrammetric method, manual diagnostics for the detection of muscular-tonic syndromes and musculoskeletal dysfunction) and Doppler ultrasound of extra- and intracranial segments of VA. It was revealed the relationship between the violation of hemodynamics in vertebrobasilar system and pathobiomechanical changes of the musculoskeletal system in patients of young age. The leading pathogenetic role in the onset of hemodynamic disorders in VA belongs to a non-optimal static stereotype in the cervical region in the form of displacement of the regional center of gravity forward with the formation of a forward head position. It was revealed a positive correlation between the value of CVA and the degree of mobility of the craniovertebral transition by A. Stoddart (r = +0.79, p <0.05) and also - a negative correlation between CVA value and the level of blood flow reduction in VA during functional rotational tests (r=-0,69, p<0,05).