Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis
Abstract
The interaction of cells with the extracellular matrix regulates cell adhesion, motility, growth, survival and differentiation through integrin-mediated signal transduction. Here we demonstrate that galectin-8, a secreted mammalian (beta)-galactoside binding protein, inhibits adhesion of human carci …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
pubmed abstract
nih
national institutes of health
national library of medicine
Cultured
carbohydrate metabolism
transfection
tumor cells
protein structure
tertiary
recombinant proteins / metabolism
apoptosis / physiology*
pmid:10852818
doi:10.1242/jcs.113.13.2385
y r hadari
r arbel-goren
y zick
binding sites / physiology*
cell adhesion / physiology*
extracellular matrix / metabolism
galectins*
growth inhibitors / metabolism
integrin alpha3beta1
integrins / metabolism*
lectins / metabolism*
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284552
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