A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS

A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS

Dai L;Zheng T;Xu K;Han Y;Xu L;Huang E;An Y;Cheng Y;Li S;Liu M;Yang M;Li Y;Cheng H;Yuan Y;Zhang W;Ke C;Wong G;Qi J;Qin C;Yan J;Gao GF;;
Cell 2020 Vol. 182 pp. -
266
l2020cella

Abstract

Vaccines are urgently needed to control the ongoing pandemic COVID-19 and previously emerging MERS/SARS caused by coronavirus (CoV) infections. The CoV spike receptor-binding domain (RBD) is an attractive vaccine target but is undermined by limited immunogenicity. We describe a dimeric form of MERS- …

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