Elevated high sensitivity C reactive protein (hs-CRP) has been identified as a strong predictor of prognosis acute coronary syndrome. The prognostic significance of hs-sensitivity CRP level in percutaneous coronary intervention (PCI) is unclear. This study is to assess the hs-CRP value and its prognostic significance in short and long term follows up after PCI. We prospectively studied 41 patients with chronic stable angina (28 patients) and unstable angina (13 patients) who underwent elective coronary stenting. All patients had normal troponin level before the procedure. Blood samples for hs-CRP were obtained before the procedure, 24 hours after the procedure and followed up at 1 month and after 2years. Mean hs-CRP before and post the procedure in all patients underwent PCI was 2.38 ± 2.21µg/ml and 7.43 ± 10.6 µg/ml respectively. There was significant difference between pre procedural hs-CRP and 24 hours post procedural (P = 0.007). At follow up period (1 month), no major adverse cardiac events (MACE) have occurred. At follow up period (2 years), MACE has occurred in 13 patients. There was a weak correlation between the level of the pre-procedural hs-CRP and occurrence of MACE (r = 0.22, P = 0.2) and no correlation between post procedural hs-CRP and occurrence of MACE. Mechanical disruption of atherosclerotic plaque during elective coronary stent implantation causes a systemic inflammatory response. Measuring of hs-CRP either pre-procedural or post procedural in low risk patients is not useful for predicting of either early or late cardiovascular events.