Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development
Abstract
We have identified two highly conserved mouse genes encoding bone morphogenetic protein 8A (BMP8A/OP2) and 8B (BMP8B). The two loci are tightly linked on chromosome 4, suggesting that they arose through a recent gene duplication. Contrary to previous reports, neither gene is expressed in the early p …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Inbred C57BL
gene expression regulation
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
female
male
amino acid sequence
P.H.S.
Molecular Sequence Data
placentation*
testis / physiology
bone morphogenetic proteins / genetics*
developmental / genetics
bone morphogenetic protein 2
b l hogan
hair follicle / growth & development
pmid:8843393
doi:10.1016/0925-4773(96)00543-6
g q zhao
multigene family / physiology*
spermatogenesis / genetics*
transforming growth factor beta / genetics*
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273977
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