Integration of regulatory networks by NKX3-1 promotes androgen-dependent prostate cancer survival
Abstract
The NKX3-1 gene is a homeobox gene required for prostate tumor progression, but how it functions is unclear. Here, using chromatin immunoprecipitation coupled to massively parallel sequencing (ChIP-seq) we showed that NKX3-1 colocalizes with the androgen receptor (AR) across the prostate cancer geno …
Keywords
Tumor
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
gene expression regulation
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
male
cell line
neoplastic*
Receptors
Promoter Regions
transcription factors / genetics*
transcription factors / metabolism
prostatic neoplasms / genetics*
protein binding
gene regulatory networks*
transcriptional activation
androgens / metabolism
cell survival
androgen / metabolism
prostatic neoplasms / metabolism
prostatic neoplasms / pathology
chromatin immunoprecipitation
prostate / metabolism
prostate / pathology
homeodomain proteins / metabolism
transcription factors / analysis
homeodomain proteins / genetics*
androgen / analysis
pmid:22083957
pmc3255774
doi:10.1128/mcb.05958-11
peck yean tan
cheng wei chang
edwin cheung
hepatocyte nuclear factor 3-alpha / metabolism
homeodomain proteins / analysis
androgen / genetics*
rab3 gtp-binding proteins / genetics
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273773
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