IL-12 gene-deficient C57BL/6 mice are susceptible to Leishmania donovani but have diminished hepatic immunopathology
Abstract
To determine the in vivo role of IL-12 in the development of protective immunity in visceral leishmaniasis caused by Leishmania donovani, we examined the course of L. donovani infection in IL-12-deficient C57BL/6 (IL-12-/-) mice. IL-12-/- mice displayed significantly higher parasite burdens in their …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Inbred C57BL
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
u.s. gov't
female
male
P.H.S.
Knockout
in vitro techniques
kinetics
spleen / immunology
lymphocyte activation
interferon-gamma / biosynthesis
interleukin-4 / biosynthesis
t-lymphocytes / immunology
leishmaniasis
visceral / immunology*
liver / parasitology
liver / pathology*
interleukin-12 / physiology
pmid:10741399
doi:10.1002/1521-4141(200003)30:33.0.co;2-9
a r satoskar
s rodig
j r david
interleukin-12 / deficiency*
interleukin-12 / genetics*
leishmania donovani* / isolation & purification
leishmania donovani* / pathogenicity
visceral / parasitology
visceral / pathology*
liver / immunology*
spleen / parasitology
spleen / pathology
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Citation
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273686
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