SIX4 promotes hepatocellular carcinoma metastasis through upregulating YAP1 and c-MET
Abstract
Metastasis is the main reason for high mortality in hepatocellular carcinoma (HCC) patients and the molecular mechanism remains unclear. Therefore, it is important to elucidate the mechanism underlying HCC metastasis. Here, we report a novel role of SIX homeobox 4 (SIX4), one of the SIX gene family, …
Keywords
Tumor
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
prognosis
research support
non-u.s. gov't
female
male
middle aged
cell line
Transcription Factors / metabolism*
transcription
carcinoma
signal transduction
cell transformation
neoplastic
neoplasm metastasis
up-regulation
liver neoplasms / genetics
liver neoplasms / diagnosis
trans-activators / metabolism*
adaptor proteins
hepatocellular / metabolism*
liver neoplasms / metabolism*
hepatocellular / pathology*
signal transducing / metabolism*
homeodomain proteins / metabolism*
pmid:33046796
doi:10.1038/s41388-020-01500-y
qin he
zhuoying lin
limin xia
hepatocellular / diagnosis
hepatocellular / genetics
liver neoplasms / pathology*
proto-oncogene proteins c-met / metabolism*
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273466
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