Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes
Abstract
Pancreatic islet beta-cell death occurs in type 1 and 2 diabetes mellitus, leading to absolute or relative insulin deficiency. beta-cell death in type 1 diabetes is due predominantly to autoimmunity. In type 2 diabetes beta-cell death occurs as the combined consequence of increased circulating gluco …
Keywords
immunity
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
review
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
Adipocytes / metabolism
Active
glucose / metabolism
apoptosis
diabetes mellitus
cytokines / metabolism
cytokines / biosynthesis
innate
type 2 / physiopathology*
insulin resistance
autoimmunity
type 2 / immunology
marc y donath
type 1 / etiology
type 1 / immunology
pmid:12879149
doi:10.1007/s00109-003-0450-y
joachim størling
thomas mandrup-poulsen
type 1 / physiopathology*
type 2 / etiology
inflammation mediators / physiology*
islets of langerhans / physiopathology*
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273226
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