Regulation of the mevalonate pathway
Abstract
The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the productio …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
review
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
P.H.S.
Receptors
gene expression regulation / drug effects
genetic / drug effects
transcription
cell division
j l goldstein
m s brown
LDL / genetics
pmid:1967820
doi:10.1038/343425a0
cholesterol / biosynthesis
farnesol / metabolism
hydroxymethylglutaryl coa reductases / genetics
hydroxymethylglutaryl-coa synthase / genetics
mevalonic acid / metabolism*
sterols / pharmacology
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273196
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