Systemic antibodies towards mucosal bacteria in ulcerative colitis and Crohn's disease differentially activate the innate immune response
Abstract
Changes in mucosal bacteria, and a switch from internal to surface antigen/antibody reactivity of a predominantly IgG1 type, leads to greater opsonisation of the respiratory burst in PMN, providing a mechanism for maintaining the inflammatory state in UC.
Keywords
immunity
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
female
male
aged
middle aged
80 and over
Antibodies
Antigens
Bacteria / isolation & purification*
intestinal mucosa / immunology
intestinal mucosa / microbiology*
Colitis
immunoglobulin g / blood
bacterial / immunology*
bacterial / blood
bacterial / immunology
surface / immunology
neutrophils / immunology
g t macfarlane
ulcerative / microbiology
immunoglobulin a / blood
bacteria / immunology
rectum / microbiology
crohn disease / microbiology
ulcerative / immunology*
pmid:14684582
pmc1773925
doi:10.1136/gut.53.1.91
e furrie
s macfarlane
crohn disease / immunology*
mucosal
rectum / immunology
respiratory burst
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Citation
ID:
272552
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