A luminal epithelial stem cell that is a cell of origin for prostate cancer
Abstract
In epithelial tissues, the lineage relationship between normal progenitor cells and cell type(s) of origin for cancer has been poorly understood. Here we show that a known regulator of prostate epithelial differentiation, the homeobox gene Nkx3-1, marks a stem cell population that functions during p …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Inbred C57BL
Kidney
gene expression regulation
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
u.s. gov't
non-p.h.s.
male
N.I.H.
Extramural
transcription factors / metabolism
cell differentiation
nude
transcription factors / genetics
cell transformation
neoplastic
epithelial cells / metabolism
cell division
pten phosphohydrolase / genetics
androgens / metabolism
castration
prostatic neoplasms / metabolism
prostatic neoplasms / pathology*
prostatic neoplasms / genetics
epithelial cells / pathology*
homeodomain proteins / metabolism
cell lineage*
regeneration
homeodomain proteins / genetics
pmid:19741607
pmc2800362
doi:10.1038/nature08361
xi wang
marianna kruithof-de julio
michael m shen
androgens / deficiency
epithelial cells / transplantation
neoplastic stem cells / metabolism
neoplastic stem cells / pathology*
neoplastic stem cells / transplantation
pten phosphohydrolase / deficiency
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272549
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