Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle
Abstract
AMP-activated protein kinase (AMPK) is a key regulator of cellular energy balance and of the effects of leptin on food intake and fatty acid oxidation. Obesity is usually associated with resistance to the effects of leptin on food intake and body weight. To determine whether diet-induced obesity (DI …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
male
N.I.H.
Extramural
Body Weight
energy metabolism
leptin / metabolism
fatty acids / metabolism
muscle
Acetyl-CoA Carboxylase / metabolism
oxygen / metabolism
amp-activated protein kinases
protein-serine-threonine kinases / physiology*
pmid:16687413
doi:10.1074/jbc.m512831200
tonya l martin
thierry alquier
barbara b kahn
animal feed*
hypothalamus / enzymology*
hypothalamus / pathology
multienzyme complexes / physiology*
skeletal / enzymology*
obesity*
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272041
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