Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance

Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance

Bastard JP;Caron M;Vidal H;Jan V;Auclair M;Vigouroux C;Luboinski J;Laville M;Maachi M;Girard PM;Rozenbaum W;Levan P;Capeau J;;
Lancet (London, England) 2002 Vol. 359 pp. -
226
jp2002lancetassociation

Abstract

The altered differentiation status of peripheral adipocytes in HIV-1-infected patients with antiretroviral-induced lipoatrophy is associated with greatly reduced SREBP1c expression. Since the differentiation factor SREBP1 is rapidly targeted by protease inhibitors in vitro, our results suggest that …

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