Physical Association of Saccharomyces cerevisiae Polo-like Kinase Cdc5 with Chromosomal Cohesin Facilitates DNA Damage Response
Abstract
At the onset of anaphase, a protease called separase breaks the link between sister chromatids by cleaving the cohesin subunit Scc1. This irreversible step in the cell cycle is promoted by degradation of the separase inhibitor, securin, and polo-like kinase (Plk) 1-dependent phosphorylation of the S …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
pubmed abstract
nih
national institutes of health
national library of medicine
mutation
cell cycle proteins / genetics
cell cycle proteins / metabolism*
amino acid substitution
saccharomyces cerevisiae / genetics
protein-serine-threonine kinases / metabolism*
saccharomyces cerevisiae / metabolism*
chromosomal proteins
protein-serine-threonine kinases / genetics
Proto-Oncogene Proteins / metabolism
mitosis*
proto-oncogene proteins / genetics
missense
saccharomyces cerevisiae proteins / genetics
saccharomyces cerevisiae proteins / metabolism*
pmid:27325700
pmc5016123
doi:10.1074/jbc.m116.727438
sujiraporn pakchuen
mai ishibashi
takashi sutani
non-histone / genetics
non-histone / metabolism*
dna damage*
phleomycins / pharmacology
phosphorylation / genetics
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270581
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