Mdm2 promotes the rapid degradation of p53
Abstract
The p53 tumour-suppressor protein exerts antiproliferative effects, including growth arrest and apoptosis, in response to various types of stress. The activity of p53 is abrogated by mutations that occur frequently in tumours, as well as by several viral and cellular proteins. The Mdm2 oncoprotein i …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
RNA
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
P.H.S.
Cultured
messenger / metabolism
recombinant fusion proteins / genetics
hela cells
transfection
protein binding
tumor cells
recombinant fusion proteins / metabolism
nuclear proteins*
proto-oncogene proteins / metabolism*
proto-oncogene proteins c-mdm2
tumor suppressor protein p53 / metabolism*
proto-oncogene proteins / genetics
tumor suppressor protein p53 / genetics
pmid:9153395
doi:10.1038/387296a0
y haupt
r maya
m oren
down-regulation / radiation effects
tumor suppressor protein p53 / antagonists & inhibitors
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270407
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