Administration National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female male aged Comparative Study 80 and over Clinical Trial Phase III Randomized Controlled Trial Double-Blind Method Multicenter Study follow-up studies neutropenia / chemically induced induction chemotherapy antineoplastic combined chemotherapy protocols / adverse effects disease-free survival prednisone / adverse effects oral neoplasms kaplan-meier estimate maintenance chemotherapy antineoplastic combined chemotherapy protocols / therapeutic use* prednisone / administration & dosage* initials='g' affs=[] is_editor=false suffix=none equal_contrib=false) initials='jp' initials='ag' initials='j' initials='a' initials='h' initials='am' initials='b' initials='n' initials='p' initials='k' author(firstnames='j' author(firstnames='g' author(firstnames='h' author(firstnames='a m' author(firstnames='p' author(firstnames='a' initials='d' affs=[]) initials='s' initials='m' initials='o' initials='f' initials='i' initials='r' initials='e' initials='v' author(firstnames='s' author(firstnames='n' author(firstnames='t' initials='t' author(firstnames='m' author(firstnames='d' author(firstnames='e' author(firstnames='k' author(firstnames='r' author(firstnames='v' initials='fj' initials='js' initials='ml' initials='z' equal_contrib=false)] lastname='mollee' lastname='prince' lastname='horvath' lastname='greil' lastname='van droogenbroeck' lastname='schots' author(firstnames='f' author(firstnames='z' author(firstnames='i' author(firstnames='o' pmid:22571200 doi:10.1056/nejmoa1112704 antonio palumbo roman hajek collabauthor(name='mm-015 investigators' investigators=[author(firstnames='b' lastname='augustson' lastname='joshua' lastname='spencer' lastname='taylor' author(firstnames='a g' lastname='gastl' lastname='ludwig' lastname='iskrov' lastname='uss' lastname='fillet' lastname='maisnar' lastname='scudla' lastname='gregersen' lastname='attal' author(firstnames='j p' lastname='fermand' lastname='jaccard' lastname='macro' author(firstnames='j -f' lastname='rossi' initials='j-' lastname='dölken' lastname='engelhardt' lastname='goldschmidt' lastname='knop' lastname='niederwieser' lastname='crotty' lastname='nagler' lastname='rowe' lastname='shpilberg' lastname='cafro' lastname='caravita' lastname='foa' lastname='gobbi' lastname='zweegman' lastname='dmoszynska' lastname='hellmann' author(firstnames='a b' lastname='skotnicki' initials='ab' lastname='abdulkadyrov' lastname='domnikova' lastname='osmanov' lastname='rossiev' lastname='rukavistin' lastname='alegre' author(firstnames='f j' lastname='capote' author(firstnames='m l' lastname='martino' author(firstnames='j s' lastname='miguel' lastname='ahlgren' lastname='bauer' lastname='stenner' lastname='cagirgan' lastname='schey' lastname='yong' lastname='kaplan' lastname='kyeting' lastname='lysa' lastname='maslyak' lastname='pylypenko' lastname='tretyak' lenalidomide melphalan / administration & dosage* melphalan / adverse effects multiple myeloma / drug therapy* multiple myeloma / mortality second primary / epidemiology thalidomide / administration & dosage thalidomide / adverse effects thalidomide / analogs & derivatives*