Methotrexate influx via folate transporters into alveolar epithelial cell line A549
Abstract
Methotrexate (MTX), a drug used for the treatment of certain cancers as well as rheumatoid arthritis, sometimes induces serious interstitial lung injury. Although lung toxicity of MTX is related to its accumulation, the information concerning MTX transport in the lungs is lacking. In this study, we …
Keywords
Tumor
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
cell line
Biological Transport / drug effects
kinetics
hydrogen-ion concentration
pmid:26190800
doi:10.1016/j.dmpk.2015.04.005
masashi kawami
mioka miyamoto
mikihisa takano
biological transport / physiology
carrier proteins / metabolism
epithelial cells / drug effects
epithelial cells / metabolism*
folic acid / metabolism*
folic acid transporters / metabolism*
methotrexate / metabolism*
proton-coupled folate transporter / metabolism
pulmonary alveoli / drug effects
pulmonary alveoli / metabolism*
sulfasalazine / pharmacology
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267936
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