Signature-tagged mutagenesis in a chicken infection model leads to the identification of a novel avian pathogenic Escherichia coli fimbrial adhesin
Abstract
The extraintestinal pathogen, avian pathogenic E. coli (APEC), known to cause systemic infections in chickens, is responsible for large economic losses in the poultry industry worldwide. In order to identify genes involved in the early essential stages of pathogenesis, namely adhesion and colonizati …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
Fibroblasts / metabolism
Chickens
mutation
microscopy
dogs
escherichia coli / metabolism
adhesins
multigene family
gene deletion
escherichia coli / metabolism*
bacterial / metabolism*
fimbriae
pmid:19907658
pmc2771359
doi:10.1371/journal.pone.0007796
esther-maria antão
christa ewers
lothar h wieler
birds
escherichia coli / genetics*
escherichia coli infections / metabolism*
genetic complementation test
electron / methods
mutagenesis*
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