Karl Marx and Friedrich Nietzsche are two figures that are considered controversial in religious studies. Both stated that ‘religion is the opium and the God is dead’ are deemed to have passed the limits of tolerance. As a result, both are regarded as insane person in their time. When they are examined more deeply, both statements expressed deep concern over the social situation of the people that suffer as a result of oppression and domination. In this situation, religion precisely be one that encourages people to behave naive and counterproductive to the objectives of humanitarian material. Thus, “religion is the opium and God is dead” are social provocation and criticism for people to get out of the traps of stagnation. The purpose of human life is material. For Marx, human nature is working, while for Nietzsche, it is the willing to power. This means that human will be humanic if it human is able to express in productive work that is free from domination and have the will to implement the powers that are pushing for continually active and creative. Initially, religion supports human to manifest true humanity but evolved into rituals that hinder the process of humanization.