The use of nicotine products among adolescents is now designated as a national epidemic by the United States Surgeon General. The largest one-year increase ever recorded for substance use in the adolescent population should sound the alarm for Nurse Practitioners (NPs) practicing in family health and pediatrics. Vaping, or the use of e-cigarettes or electronic nicotine delivery systems (ENDS), has been purported by the vaping industry as a less harmful alternative for tobacco users in their attempt to quit smoking. In adolescents, vaping represents a dangerous and highly addictive health behavior. Initiatives on both the state and federal levels have begun to address marketing and access to young users. However, the active involvement of NPs on the front line of primary care will be necessary to combat this imposing threat. The protection of our young patients from nicotine addiction and the education of patients and families about the potential dangers of e-cigarettes are imperative to prevent harm. This article addresses concerns related to e-cigarette use in the adolescent population and the important role NPs can play in promoting their health and well-being.