Increasing attention is being paid to the energy efficiency in metro systems to reduce the operational cost and to advocate the sustainability of railway systems. Classical research has studied the energy-efficient operational strategy and the energy-efficient system design separately to reduce the traction energy consumption. This paper aims to combine the operational strategies and the system design by analyzing how the infrastructure and vehicle parameters of metro systems influence the operational traction energy consumption. Firstly, a solution approach to the optimal train control model is introduced, which is used to design the Optimal Train Control Simulator(OTCS). Then, based on the OTCS, the performance of some important energy-efficient system design strategies is investigated to reduce the trains’ traction energy consumption, including reduction of the train mass, improvement of the kinematic resistance, the design of the energy-saving gradient, increasing the maximum traction and braking forces, introducing regenerative braking and timetable optimization. As for these energy-efficient strategies, the performances are finally evaluated using the OTCS with the practical operational data of the Beijing Yizhuang metro line. The proposed approach gives an example to quantitatively analyze the energy reduction of different strategies in the system design procedure, which may help the decision makers to have an overview of the energy-efficient performances and then to make decisions by balancing the costs and the benefits.