Enhancement of respiratory syncytial virus pulmonary pathology in cotton rats by prior intramuscular inoculation of formalin-inactiva ted virus
Abstract
Cotton rats previously inoculated with Formalin-inactivated respiratory syncytial virus (RSV) were challenged intranasally with live RSV to induce an enhancement of RSV disease similar to that observed after the administration of Formalin-inactivated RSV vaccine to human infants 20 years ago. Within …
Keywords
injections
immunization
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
Antibodies
Viral / analysis
respiratory syncytial viruses / immunology*
passive
vaccines
r m chanock
virus replication
g a prince
arvicolinae
epitopes / analysis
viral vaccines / pharmacology*
respiratory syncytial viruses / pathogenicity
glycoproteins / immunology
lung / pathology*
intramuscular
attenuated / pharmacology
pmid:2419587
pmc252798
doi:10.1128/jvi.57.3.721-728.1986
a b jenson
formaldehyde / pharmacology*
neutrophils / pathology
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120136
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