Boceprevir for untreated chronic HCV genotype 1 infection
Abstract
The addition of boceprevir to standard therapy with peginterferon-ribavirin, as compared with standard therapy alone, significantly increased the rates of sustained virologic response in previously untreated adults with chronic HCV genotype 1 infection. The rates were similar with 24 weeks and 44 we …
Keywords
hepatitis c
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
RNA
humans
pubmed abstract
nih
national institutes of health
national library of medicine
treatment outcome
research support
non-u.s. gov't
adult
female
male
middle aged
Comparative Study
Clinical Trial
Phase III
Randomized Controlled Trial
Double-Blind Method
Multicenter Study
Genotype
viral / blood
drug therapy
combination
antiviral agents / therapeutic use*
recombinant proteins
viral load
ribavirin / therapeutic use
hepacivirus / isolation & purification
chronic / virology
african continental ancestry group
antiviral agents / adverse effects
hepacivirus / genetics*
chronic / drug therapy*
interferon alpha-2
serine proteinase inhibitors / adverse effects
serine proteinase inhibitors / therapeutic use*
pmid:21449783
pmc3766849
doi:10.1056/nejmoa1010494
fred poordad
jonathan mccone
sprint-2 investigators
anemia / chemically induced
chronic / ethnology
interferon-alpha / therapeutic use
polyethylene glycols / therapeutic use
proline / adverse effects
proline / analogs & derivatives*
proline / therapeutic use
Access
Citation
ID:
117918
References
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