Cytotoxic T cells clear virus but augment lung pathology in mice infected with respiratory syncytial virus
Abstract
We have examined the function of class I MHC-restricted cytotoxic T cells in experimental respiratory syncytial virus (RSV) infection of BALB/c mice by transfer of T cell line MJC-A2 and CTL clone E8a into RSV-infected mice. The T cell line cleared pulmonary RSV infection within 5 d in persistently …
Keywords
immunization
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
Inbred BALB C
passive
lung / microbiology
respiratory syncytial viruses / immunology
t-lymphocytes
lung / immunology
respirovirus infections / immunology*
cytotoxic / immunology*
p j openshaw
respirovirus infections / pathology
respirovirus infections / microbiology
pmid:3262705
pmc2189034
doi:10.1084/jem.168.3.1163
m j cannon
b a askonas
clone cells
dimercaprol
lung / pathology*
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115312
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