Recently, the interest around the Blockchain concept has grown faster and, as a consequence, several studies about the possibility of exploiting such technology in different application domains have been conducted. Most of these studies highlighted the benefits that the use of the blockchain could bring in those contexts where integrity and authenticity of the data are important, e.g., for reasons linked to regulations about consumers’ healthcare. In such cases, it would be important to collect data, coming in real-time through sensors, and then store them in the blockchain, so that they can become immutable and tamper-proof. In this paper, the design and development of a software framework that allows Internet-of-Things (IoT) devices to interact directly with an Ethereum-based blockchain are reported. The proposed solution represents an alternative way for integrating a wide category of IoT devices without relying on a centralized intermediary and third-party services. The main application scenario for which the project has been conceived regards food-chain traceability in the Industry 4.0 domain. Indeed, the designed system has been integrated into the depiction of a use case for monitoring the temperature of fish products within a warehouse and during the delivery process.