Data on charge separation of bispecific and mispaired IgGs using native charge-variant mass spectrometry.
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Data on charge separation of bispecific and mispaired IgGs using native charge-variant mass spectrometry.

Phung, Wilson;Han, Guanghui;Polderdijk, Stéphanie G I;Dillon, Michael;Shatz, Whitney;Liu, Peter;Wei, Bingchuan;Suresh, Pawankumar;Fischer, David;Spiess, Christoph;Bailey, Aaron;Carter, Paul J;Lill, Jennie R;Sandoval, Wendy;
Data in brief 2020 Vol. 30 pp. 105435
193
phung2020datadata

Abstract

The data supplied in this work are related to the research article entitled "Characterization of Bispecific and Mispaired IgGs by Native Charge-Variant Mass Spectrometry" (Phung et al., 2019). This data article describes a powerful analytical platform using native weak cation exchange chromatography coupled to a high-resolution mass spectrometer, charge variant mass spectrometry (CV-MS), to characterize bispecific and mispaired antibody species. Elution order is investigated through analytical methods and molecular modeling in an effort to understand the intrinsic charge, size and shape differences of these molecules.

Keywords

single cell native mass spectrometry ion exchange chromatography bispecific antibody charge variant mass spectrometry cognate pairs molecular model weak cation exchange

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DOI:
10.1016/j.dib.2020.105435

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