Diagnosis and treatment of synchronous multiple primary lung cancer – a case report
Abstract
Yi Bao,1,2 Jiayuan Wu,1 Jun Zhang,3 Yawei Yu41The Key Laboratory, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, People’s Republic of China; 2The Department of Oncology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, People’s Republic of China; 3The Department of Thoracic Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, People’s Republic of China; 4The Department of Pathology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, People’s Republic of ChinaAbstract: The incidence of synchronous multiple primary lung cancer (SMPLC) has been increased in recent years. Because of a variance in clinical management and outcome, it is important to distinguish SMPLC from a primary tumor with intrapulmonary metastases. Here, we reported a diagnosis and treatment procedure regarding a case of a 58‐year‐old woman who presented with synchronous multiple tumor lesions in separate lungs. Using a next generation sequencing technology, a discordant EGFR gene profile from the separate lungs was revealed for this patient. After standard treatment procedures, the therapeutic effects were evaluated by response evaluation criteria in solid tumors (RECIST). This case shows an essential role in the combination of molecular features, together with pathological analysis, during the management of SMPLC, but challenges still required considering during dealing the cases of SMPLC.Keywords: lung adenocarcinoma, SMPLC, genetic features, EGFR
Keywords
chemistry
Biology (General)
Chemical technology
Engineering (General). Civil engineering (General)
Technology
physics
environmental sciences
neoplasms. tumors. oncology. including cancer and carcinogens
nutrition. foods and food supply
agriculture
social sciences
urban groups. the city. urban sociology
regional planning
home economics
geography. anthropology. recreation
recreation. leisure
human ecology. anthropogeography
communities. classes. races
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