This paper discusses humanist translations of Greek patristic texts dedicated to Pope Nicholas V. Patristic studies were particularly relevant for his pontificate, which followed the Council of Ferrara-Florence and witnessed the conquest of Constantinople by the Ottoman Turks. Nicholas's patronage was informed by his wish to unite the eastern and the western church, make Rome the ultimate capital of the Christian world, and preserve the literary heritage of the Byzantine empire. To determine the role patristics played in his translation project, this paper situates the patristic translations dedicated to him in the context of his translation patronage and collecting activities.