Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease
Abstract
The secreted Frizzled-related proteins (SFRPs) are a family of soluble proteins that are structurally related to Frizzled (Fz) proteins, the serpentine receptors that mediate the extensively used cell-cell communication pathway involving Wnt signalling. Because of their homology with the Wnt-binding …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
review
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
neoplasms / metabolism
signal transduction
pmid:18322270
doi:10.1242/jcs.026096
paola bovolenta
pilar esteve
javier lopez-rios
frizzled receptors / metabolism
glycoproteins / chemistry
glycoproteins / classification
glycoproteins / physiology*
growth and development
intracellular signaling peptides and proteins
wnt proteins / antagonists & inhibitors*
wnt proteins / metabolism
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269469
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