Changes in 5-HT7 serotonin receptor mRNA expression with aging in rat brain
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Changes in 5-HT7 serotonin receptor mRNA expression with aging in rat brain

R Kohen,D.E.A Heidmann,J Anthony,S.S White,M.W Hamblin,P Szot;R Kohen;D.E.A Heidmann;J Anthony;S.S White;M.W Hamblin;P Szot;
Molecular Brain Research 2000 Vol. 79 pp. 163-168
231
szot2000molecularchanges

Abstract

We examined 5-HT7 receptor mRNA expression with in situ hybridization histochemistry in the brains of young (3 months), middle-aged (12 months) and old rats (24 months). In the ventral CA3 area of the hippocampus 5-HT7 mRNA expression is reduced by approximately 30% between young and middle age without further decline between middle and old age. In other brain areas 5-HT7 mRNA expression is unaffected by age.

Keywords

aging hippocampus psychiatric disorders circadian rhythm spatial learning in situ hybridization histochemistry

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DOI:
10.1016/s0169-328x(00)00103-0
URL:
https://sciprofiles.com/publication/view/90ca7dd58...

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ID: 269062
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