Background: Hospital wastes are considered as a serious threat for public health. Hospital waste management may help to control disease transmission and have remarkable economic advantages. The purpose of this study was to assess  the hospitals' waste management in Isfahan, Iran in 2014. Methods: Data of this descriptive and cross-sectional study were collected through a check list for surveying hospital waste management. Validity of checklist was confirmed by analysis of face validity and field experts' opinions. Cronbach's alpha of 0.80 was calculated. Data were then analyzed using descriptive statistics in Excell software. Results: In the studied hospitals "Elimination" dimension was inappropriate while the "Human resources involved in waste management" dimension was estimated relatively appropriate. Other dimensions were estimated as appropriate. Infectious wastes consisted of about 10.89 % of the total wastes in hospitals and the average of waste generation for each bed was 3.67 kg per day. There was no environmental unit in the studied hospitals and only one of them did not have waste management unit. Conclusion: Despite the fact that waste management status in hospitals under study was relatively appropriate, but given the importance of the issue, it is essential to improve the current situation especially in some aspects of waste management.