Background: Pelvic organ prolapse can have a detrimental effect on woman's quality of life by limiting physical, social, psychological, and sexual functions. We determined the prevalence, predisposing factors, and complications of pelvic organ prolapse at the Usmanu Danfodiyo University Teaching Hospital (UDUTH), Sokoto. Materials and Methods: A retrospective study of the cases of pelvic organ prolapse managed at UDUTH, Sokoto, between January 1, 2003, and December 31, 2012. Results: The prevalence of pelvic organ prolapse was 1.4% of all gynecological admissions. The mean age of the patients was 45.3 ± 16.1 years. Majority of the patients, i.e., 63.7% were premenopausal. The grand multiparous women constituted 65.9% of the patients. The most common presenting symptom was a mass protruding through the vagina. The prolapsing organs included uterus 75.8%, bladder 12.1%, rectum 6.6%, and a combination of bladder and rectum 5.5%. The most common predisposing factor identified was unsupervised home delivery. Most of the patients had surgical intervention that included vaginal hysterectomy 59.3%, anterior colporrhaphy 7.7%, posterior colpoperineorrhaphy 6.6%, and combined anterior colporrhaphy and posterior colpoperineorrhaphy 5.5%. Hemorrhage was the most common intraoperative complication encountered in anemia 10.7% and wound infection 2.7% was most prevalent in the postoperative period. Conclusion: Multiparity, prolonged labor, and unsupervised deliveries were significant predisposing factors of pelvic organ prolapse antenatal care; skilled supervised deliveries and access to effective family planning methods will decrease the prevalence.