Inhibitory effect of pyridobenzazoles on virus replication in vitro
Abstract
Twelve species of pyridobenzazoles and pyrimidobenzimidazole were examined as inhibitors of the replication of respiratory syncytial virus (RSV) in HeLa cells. From the pyridobenzazoles studied, 2-benzamido-4-cyano-1-oxo-1H,5H-pyrido[1,2-alpha]benzimidazol emerged as a potent inhibitor of the RSV. B …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
Cells
Cultured
respiratory syncytial viruses / drug effects*
antiviral agents / pharmacology*
hela cells
influenza a virus / drug effects*
influenza a virus / physiology
simplexvirus / physiology
respiratory syncytial viruses / physiology
cytopathogenic effect
viral / drug effects
s shigeta
pmid:8535400
doi:10.1248/bpb.18.1081
t chiba
y numazaki
benzimidazoles / pharmacology*
simplexvirus / drug effects*
virus replication / drug effects*
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117510
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