The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
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The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

Ricketts CJ;De Cubas AA;Fan H;Smith CC;Lang M;Reznik E;Bowlby R;Gibb EA;Akbani R;Beroukhim R;Bottaro DP;Choueiri TK;Gibbs RA;Godwin AK;Haake S;Hakimi AA;Henske EP;Hsieh JJ;Ho TH;Kanchi RS;Krishnan B;Kwiatkowski DJ;Lui W;Merino MJ;Mills GB;Myers J;Nickerson ML;Reuter VE;Schmidt LS;Shelley CS;Shen H;Shuch B;Signoretti S;Srinivasan R;Tamboli P;Thomas G;Vincent BG;Vocke CD;Wheeler DA;Yang L;Kim WY;Robertson AG; ;Spellman PT;Rathmell WK;Linehan WM;;
Cell reports 2018 Vol. 23 pp. -
465
cj2018cellthe

Abstract

Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, a …

Keywords

National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support N.I.H. Extramural genome phenotype metabolic networks and pathways Survival Analysis transcription factors / metabolism carcinoma nuclear proteins / metabolism biomarkers human* transcription factors / genetics nuclear proteins / genetics pmid:29617669 pmc6075733 doi:10.1016/j.celrep.2018.03.075 christopher j ricketts aguirre a de cubas w marston linehan tumor / genetics* tumor / immunology tumor / metabolism renal cell / genetics* renal cell / metabolism renal cell / pathology cyclin-dependent kinase inhibitor p16 / genetics cyclin-dependent kinase inhibitor p16 / metabolism kidney neoplasms / genetics* kidney neoplasms / metabolism kidney neoplasms / pathology pten phosphohydrolase / genetics pten phosphohydrolase / metabolism tumor suppressor proteins / genetics ubiquitin thiolesterase / genetics

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