Reduced Neuronal cAMP in the Nucleus Accumbens Damages Blood-Brain Barrier Integrity and Promotes Stress Vulnerability

Reduced Neuronal cAMP in the Nucleus Accumbens Damages Blood-Brain Barrier Integrity and Promotes Stress Vulnerability

Zhang Y;Lu W;Wang Z;Zhang R;Xie Y;Guo S;Jiao L;Hong Y;Di Z;Wang G;Aa J;;
Biological psychiatry 2020 Vol. 87 pp. -
235
y2020biologicalreduced

Abstract

Chronic social stress diminished cAMP synthesis in neurons, thus damaging BBB integrity in the NAc and promoting stress vulnerability. These results characterize neuron-produced cAMP in the NAc as a biological mechanism of neurovascular pathology in social stress.

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