In this paper the relationship between lipophilic grape seed proanthocyanidin (LGSP) and acrylamide formation in potato-based products was investigated. The acrylamide, reducing sugar, asparagine, and 3-aminopropionamide contents were determined by high performance liquid chromatography-mass spectrometry (HPLC-MS). Sensory evaluation was used to evaluate the quality of the products. The results showed that LGSP presented greater inhibition effect on the acrylamide formation than the commonly used commercial antioxidants. And 81.5% and 84.7% of acrylamide reduced in potato crisps and French fries after adding 0.1% and 0.05% LGSP (w/w) in palm oil, respectively. When the concentrations of LGSP were less than 0.1%, there was no significant difference between LGSP-treated samples and control sample for sensory evaluation. Thus, LGSP is effective in reducing the level of acrylamide and maintaining the reasonable sensory attributes of potato fried foods. The results indicate that LGSP may be used as a potential additive for reducing acrylamide formation in fried foods. This article is protected by copyright. All rights reserved.