Honey has been used since ancient times as part of traditional medicine. Several aspects of this use indicate that it also has functions such as antibacterial, antioxidant, antitumor, anti-inflammatory, antibrowning, and antiviral based on the components. Biological activities of honey, and other bee products (propolis, bee bread and royal jelly are mainly attributed to the phenolic compounds such as flavonoids. Flavonoids have been reported to exhibit a wide range of biological activities, including antibacterial, antiviral, anti-inflammatory, antiallergic, and vasodilators actions. In addition, flavonoids inhibit lipid peroxidation, platelet aggregation, capillary permeability and fragility, and the activity of enzyme systems including cyclo-oxygenase and lipoxygenase. The present study demonstrates that honey phenolic compounds are partially responsible for honey antioxidant activity, displaying the relevance of honey as both healthy foodstuff and source of antioxidant. Functional foods are an emerging field in food science due to their increasing popularity with health-conscious consumers.