Developmental programming: impact of prenatal testosterone excess on insulin sensitivity, adiposity, and free fatty acid profile in postpubertal female sheep
Abstract
Prenatal T excess causes reproductive and metabolic disruptions including insulin resistance, attributes of women with polycystic ovary syndrome. This study tested whether increases in visceral adiposity, adipocyte size, and total free fatty acids underlie the insulin resistance seen in prenatal T-t …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
pregnancy
research support
female
N.I.H.
Extramural
sex factors
Fatty Acids
pmid:23525243
pmc4016698
doi:10.1210/en.2012-2145
a veiga-lopez
j moeller
v padmanabhan
adiposity / drug effects*
embryonic development / drug effects*
embryonic development / physiology*
nonesterified / metabolism*
insulin resistance* / physiology
metabolome / drug effects
prenatal exposure delayed effects* / chemically induced
prenatal exposure delayed effects* / metabolism
prenatal exposure delayed effects* / physiopathology
sexual maturation / drug effects
sexual maturation / physiology
sheep / embryology
sheep / growth & development
sheep / metabolism
sheep / physiology
testosterone / pharmacology*
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111463
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