Natural Products Research Group Of Prof. E. Dilip De Silva

Research 

A majority of the pharmaceuticals in clinical use today (especially antibiotics and anticancer agents) have their origins in nature, isolated mainly from terrestrial plants and soil microorganisms. Sri Lanka is a tropical island with exceptionally high biodiversity and endemism thus becomes an attractive location for the discovery of new natural products with useful biological activities.

Our research program is focused on the discovery, isolation and structure determination of novel biologically active natural products from a variety of Sri Lankan organisms. For this purpose we initially screen extracts of various organisms in antibacterial bioassays to identify extracts with potent activities and then further subject these extracts to bio assay guided fractions using a variety of chromatographic methods in order to isolate the active natural products. The structures of these compounds are determined by the application of a variety of spectroscopic methods including advanced NMR spectroscopy.

As some of the latest spectroscopic methods are not available in Sri Lanka we collaborate with Professor Raymond Andersen of The University of British Columbia, Canada for this purpose. Our research has been highly productive and has led to the isolation of a large number of novel compounds with useful biological activities. Currently we are investigating a number of medicinal plants, marine algae and endophytic fungi isolated from various ecological niches for the presence of antibacterial and anticancer compounds. In addition we have also directed our attention to a largely untapped resource in Sri Lanka, the marine organisms, especially, marine algae and sponges as a source of novel compounds