Murphy Lab - Synthesis
- Home Page
- Research Interests
- Group Members 0
- Publications 0
- Projects 0
Welcome to the Murphy Lab
We like to play around with hypervalent iodine reagents. Whether it's developing new methods for carbene formation, or for a-carbonyl functionalization, hypervalent iodine is the key. And, should our newly-developed methods lend themselves to the synthesis of a natural product, we will gladly accept the challenge.
Graduate and Undergraduate students:
We are always looking for motivated students to join our team. Those interested in carrying out Chem392 or Chem494 projects, as well as internships, exchanges or co-op placements in our labs are encouraged to contact Dr. Murphy.
Prospective graduate students are invited to contact Dr. Murphy regarding positions available. Offers of a graduate position can only be made upon admission to the graduate program at the University of Waterloo. International students are strongly encouraged to review the admission requirements to assess their eligibility, and to apply early.
Home Page
Group Leader
Group Updates
Research Interests
Research areas
Our research group focuses on the use of hypervalent iodine (HVI) reagents as a method of organic synthesis. In our lab, we use HVI reagents to add halogens to molecules and produce cyclopropane systems.
Radiofluorination is a technology at the centre of the development of imaging probes for positron-emitting tomography (PET). What sets apart hypervalent iodine-based reagents in fluorination is their ability to effectively transfer an "F+" synthon, therefore reversing the polarity of the fluoride (F-) obtained from standard cyclotron sources. In order to successfully conduct the project, Leanne focuses on the design of hypervalent iodine precursors which will both readily undergo ligand exchange with fluoride and allow for facile purification of the fluorinating agent before the reaction with the scaffold of interest (probe).
As iodonium ylides are only operative for methylenes flanked by two electron withdrawing substituents, we are trying to prepare monocarbonyl iodonium ylides (MCIYs), and explore their efficacy as metallocarbene precursors. MCIYs can be generated in situ from Wittig reagents, which then act as carbene precursors.
Group Members
Publications
Edit Publication
Projects
No Projects