Predictors of insufficient amikacin peak concentration in critically ill patients receiving a 25 mg/kg total body weight regimen
Abstract
Despite an amikacin dose of 25 mg/kg of total body weight, 33% of patients still had an amikacin Cmax < 60 mg/L. Positive 24-h fluid balance was identified as a predictive factor of Cmax < 60 mg/L. When total body weight is used, low BMI tended to be associated with amikacin underdosing. These …
Keywords
injections
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
female
male
aged
middle aged
Prospective Studies
risk factors
body mass index
multivariate analysis
observational study
anti-bacterial agents / administration & dosage*
dose-response relationship
drug
intensive care units
critical illness
intravenous
body weight*
infusions
gram-negative bacterial infections / drug therapy
amikacin / administration & dosage*
pmid:24687298
doi:10.1007/s00134-014-3276-x
etienne de montmollin
lila bouadma
romain sonneville
amikacin / blood*
anti-bacterial agents / blood*
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272824
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