Phospho-β-catenin expression in primary and metastatic melanomas and in tumor-free visceral tissues, and associations with expression of PD-L1 and PD-L2
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Phospho-β-catenin expression in primary and metastatic melanomas and in tumor-free visceral tissues, and associations with expression of PD-L1 and PD-L2

Pinczewski J;Obeng RC;Slingluff CL;Engelhard VH;;
pathology, research and practice 2021 Vol. 224 pp. -
175
j2021pathology,phospho-β-catenin

Abstract

β-catenin (βcat) is an important downstream effector in the Wnt signaling pathway and plays important roles in the development and progression of many cancers including melanoma. βcat expression is regulated by GSK-3β-mediated phosphorylation at positions 33, 37 and 41. In normal cells, phosphorylat …

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National Center for Biotechnology Information NCBI NLM MEDLINE pubmed abstract nih national institutes of health national library of medicine pmid:34167064 doi:10.1016/j.prp.2021.153527 joel pinczewski rebecca c obeng victor h engelhard

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