Chronic testosterone treatment induces selective insulin resistance in subcutaneous adipocytes of women
Abstract
Adipose tissue plays a central role in determining whole body insulin sensitivity. Several aspects of adipose cell function are regulated by androgens. Given that high androgen levels and insulin resistance are linked in women, we proposed that androgens may influence insulin-mediated glucose metabo …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
adult
female
Cells
Cultured
Proto-Oncogene Proteins c-akt / metabolism
Insulin Resistance*
Biological Transport / drug effects
Cell Differentiation / drug effects
flutamide / pharmacology
glucose / metabolism
adipocytes / metabolism*
testosterone / pharmacology*
analysis of variance
polycystic ovary syndrome / metabolism
hypoglycemic agents / pharmacology
signal transduction
reverse transcriptase polymerase chain reaction
insulin / metabolism
phosphorylation
insulin / pharmacology
insulin receptor substrate proteins
pmid:17332526
doi:10.1677/joe.1.07070
a corbould
cyproterone acetate / pharmacology
phosphoproteins / metabolism
protein kinase c / metabolism
subcutaneous fat / metabolism*
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265685
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