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Review

Molecular Mechanisms and Therapeutic Strategies in Cutaneous Aging: A Comprehensive Review

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Mayada Luqman
JO MO Bio Ino, 2025, 1 (1), 5-6, ISSN
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Abstract

Skin aging is a complex biological process influenced by the interplay of intrinsic (chronological) and extrinsic (environmental) factors, culminating in visible changes such as wrinkles, laxity, and dyspigmentation. Intrinsic aging results from endogenous oxidative stress and cellular senescence, leading to reduced fibroblast proliferation, diminished collagen synthesis (notably types I and III), and fragmentation of elastin fibers. Concurrently, extrinsic aging, primarily mediated by chronic ultraviolet (UV) exposure (photoaging), exacerbates these effects through upregulation of matrix metalloproteinases (MMPs), degradation of extracellular matrix (ECM) components, and accumulation of abnormal elastin (solar elastosis). Additional contributors include decreased hyaluronic acid production, impaired barrier function, and accumulation of advanced glycation end products (AGEs). Modern anti-aging strategies target these pathways via retinoids, antioxidants, and cosmeceuticals aimed at collagen stimulation, oxidative stress neutralization, and epidermal rejuvenation. Understanding these mechanisms is critical for developing evidence-based interventions to mitigate cutaneous aging.

Keywords skin aging antioxidants photoaging Anti-aging agents Cutaneous aging Collagen degradation Wrinkle formation
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The team behind this paper

1 author, 1 institution.

This paper Muğla üniversitesi Muğla üniversitesi 1 author Mayada Luqman ML Mayada Luqman

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327 reads over 18 months.

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May 2025 October 2026

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Bibliographic Information

Mayada Luqman (2025). Molecular Mechanisms and Therapeutic Strategies in Cutaneous Aging: A Comprehensive Review, SciMatic Journal of Molecular Bio-Innovations, 1(1): 5-6
Bibtex Citation
@review{name_not_found2025jmbi,
author = {Mayada Luqman},
title = {Molecular Mechanisms and Therapeutic Strategies in Cutaneous Aging: A Comprehensive Review},
journal = {SciMatic Journal of Molecular Bio-Innovations},
year = {2025},
volume = {1},
number = {1},
pages = {5-6},
doi = {},
url = {https://scimatic.org/show_manuscript/5255}
}
APA Citation
Luqman, M., (2025). Molecular Mechanisms and Therapeutic Strategies in Cutaneous Aging: A Comprehensive Review. SciMatic Journal of Molecular Bio-Innovations, 1(1), 5-6. https://doi.org/

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