An important part of the therapeutic process of patients with lung cancer undergoing palliative chemotherapy is to assess their mental well-being. Evaluation of the sense of coherence and acceptance of the disease, which reflects the degree of adaptation of the patient to live with the disease, provides information on this topic.The primary objective was to assess the level of sense of coherence and acceptance of the disease in patients with lung cancer during palliative chemotherapy as well as coherence and acceptance together with socio-demographic factors. The secondary objective was to assess the economic impact of lung cancer on these patients.The study involved 100 patients with lung cancer during palliative chemotherapy. The study was conducted using the Sense of Coherence Questionnaire (SOC-29), the Acceptance of Illness Scale, and a socio-demographic questionnaire.The study group consisted mainly of men (66%), people with primary/vocational education (63%) and patients living in cities (59%). The average age of respondents was 62.8 years. 45% of patients had a high level of sense of coherence, and 44% had an average level. The average overall score of SOC was 143.9 points inside the upper range of average results. Levels of a sense of comprehensibility, manageability, and meaningfulness remained in close relation to the average level: 48.91, 51.33, and 43.66 points, respectively. The average acceptance of the disease was 45% with the average total of 27.21 points.Most patients during palliative chemotherapy because of lung cancer had average or high level of coherence and acceptance of the disease. The level of sense of coherence and acceptance of the disease was not affected by gender, age, education, or place of residence. Almost all patients incur costs associated with treatment, and in some of them the disease affected the source of income.